17 β -Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α
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17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α
UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the role of estrogen in the regulation of UGT1A9 expression remains unknown. In this study, we investigated the effect of 17β-estradiol (E2) on UGT...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2016
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2016.04.005